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滴眼剂系以主药(常加附加剂)用蒸餾水或植物油为溶媒,配成一种無菌、借滴瓶或滴管滴入眼粘膜的液体制剂;作麻醉、杀菌、收斂、散瞳、縮瞳及診断等用。一般規定药液应澄清無不溶物,但某些药品因溶解度关系(如醋酸腎上腺皮質素及醋酸氫化腎上腺皮質素等),可使其成極細粉末,配成乳狀混悬液。一、配制应注意事項滴眼剂的配制操作一般均較簡單,即將主药与附加剂以溶媒溶解;油剂可根据药物性質不同,加微温帮助溶解。但应注意下列数点: (1)最好採用无菌操作法制备,並适当考虑加入防腐剂。据文献报告,由于滴眼剂內帶菌或使用时的污染,常引起許多眼病。因此,决不应忽視此一問題;(2)所用的药物与溶媒,
Eye drops to the main drug (often added additives) with distilled water or vegetable oil as a solvent, dubbed a sterile, by dropping the bottle or dropper into the eye mucosa of liquid preparations; for anesthesia, sterilization, convergence, mydriasis, Use miosis and diagnosis. General provisions of the liquid should be clarified without insoluble matter, but some drugs due to solubility (such as acetate adrenocortical and hydrocortisone acetate, etc.), can make it into a very fine powder, dubbed emulsion suspension. First, the preparation should pay attention to matters The preparation of eye drops are generally more simple to prepare, the main drug and the adjuvant to dissolve the solvent; oil can be different according to the nature of the drug, plus tepid to help dissolve. However, the following points should be noted: (1) It is best to prepare by aseptic technique with due consideration for the addition of preservatives. According to the literature, many ophthalmic diseases are often caused by contamination in the eye drops or in use. Therefore, this issue should never be overlooked; (2) the drugs and solvents used,