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目的 探讨胃癌组织中C -erbB - 2和p5 3的表达及其与胃癌生物学行为的关系。方法 应用免疫组化S -P法检测 5 1例胃癌中C -erbB - 2和p5 3的表达情况。结果 5 1例胃癌中C -erbB - 2和p5 3的阳性表达率分别为2 3 5 %和 41 5 %。周围非癌性部分的组织均未见阳性表达。C -erbB - 2阳性表达与胃癌的分化程度有关 ;p5 3阳性表达与淋巴结转移有关。C -erbB - 2与p5 3阳性表达之间无明显相关性。结论 C -erbB - 2和p5 3联合检测 ,对胃癌的早期诊断和预后判断具有一定的实用价值。
Objective To investigate the expression of C-erbB-2 and p5 3 in gastric cancer and their relationship with the biological behavior of gastric cancer. Methods The expression of C-erbB-2 and p5 3 in 51 gastric carcinomas was detected by immunohistochemical S-P method. Results The positive expression rates of C-erbB-2 and p5 3 in 51 cases of gastric cancer were respectively 23.5% and 41.5%. No non-cancerous tissue around the positive expression. The positive expression of C-erbB-2 is related to the differentiation of gastric cancer. The positive expression of p5 3 is related to lymph node metastasis. There was no significant correlation between C-erbB-2 and p5 3 positive expression. Conclusion Combined detection of C-erbB-2 and p5 3 has some practical value in the early diagnosis and prognosis of gastric cancer.