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目的观察奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的临床疗效。方法将符合病例入选标准的60例患者随机分为观察组、对照组。2组均给予阿司匹林、舒血宁注射液等常规治疗,观察组同时加用奥扎格雷钠80mg静脉滴注,每日2次。2组均以连续治疗2周为1个疗程,治疗1个疗程后观察临床疗效。结果观察组痊愈率为36.67%,对照组痊愈率为20.00%,2组相比差异有统计学意义(P<0.05);观察组总有效率为76.67%,对照组总有效率为66.67%,2组相比差异有统计学意义(P<0.05)。全血高、中、低切黏度,血浆黏度,红细胞压积,血小板最大聚集率2组治疗前后组内相比差异有统计学意义(P<0.05);2组治疗后组间相比差异亦有统计学意义(P<0.05)。2组治疗前神经功能缺损程度评分组间相比差异无统计学意义(P>0.05);治疗后第7d、第14d与治疗前相比差异有统计学意义(P<0.05);治疗后第14d 2组组间相比差异有计学意义(P<0.05)。结论奥扎格雷钠联合舒血宁注射液治疗急性脑梗死临床疗效显著,可改善血液流变学指标,改善神经缺损。
Objective To observe the clinical efficacy of sodium ozagrel combined with Shuxuening injection in the treatment of acute cerebral infarction. Methods Sixty patients who met the criteria of the case were randomly divided into observation group and control group. 2 groups were given aspirin, Shuxuening injection and other conventional treatment, the observation group plus Ozagrel sodium 80mg intravenous infusion, 2 times a day. The two groups were treated continuously for 2 weeks for a course of treatment, after a course of treatment observed clinical efficacy. Results The cure rate was 36.67% in the observation group and 20.00% in the control group. The difference between the two groups was statistically significant (P <0.05). The total effective rate was 76.67% in the observation group and 66.67% in the control group. The difference between the two groups was statistically significant (P <0.05). There were significant differences between the two groups before and after treatment (P <0.05), the difference between the two groups after treatment was also significant There was statistical significance (P <0.05). There was no significant difference between the two groups in the score of neurological deficit before treatment (P> 0.05), but the difference was statistically significant (P <0.05) between the 7th and 14th days after treatment. There was significant difference between the 14d 2 groups (P <0.05). Conclusion Ozagrel sodium combined with Shuxuening injection has obvious curative effect on acute cerebral infarction. It can improve hemorrheological indexes and improve nerve defect.