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目的探讨维吾尔族口腔鳞状细胞癌(OSCC)患者血清中鳞状细胞癌抗原(SCC-Ag)的表达。方法采用化学发光法检测90例维吾尔族OSCC患者(OSCC组)和90例维吾尔族其他口腔恶性肿瘤患者(口腔非OSCC恶性肿瘤组)、101例维吾尔族口腔良性肿瘤患者(良性肿瘤组)和120例维吾尔族正常对照者(正常组)的血清SCC-Ag水平,并对其中60例OSCC和60例口腔非OSCC恶性肿瘤患者治疗前后SCC-Ag水平进行检测,分析SCC-Ag在OSCC诊断、治疗疗效中的意义。结果OSCC组的SCC-Ag水平明显高于口腔非OSCC恶性肿瘤组(P=0.002),良性肿瘤组(P=0.001)和正常组(P=0.001)。OSCC患者血清SCC-Ag阳性串为43.3%(39/90),明显高于其他3组(P=0.0001)。OSCC患者TNM晚期的术前SCC-Ag水平的表达高于早期水平(P<0.05)。复发组和未复发组的术前、术后、放化疗后SCC-Ag水平相比较,差异均有统计学意义(P<0.05)。手术及放化疗前后鳞状细胞癌患者血清SCC-Ag水平变化差异有统计学意义(P<0.01),然而,在口腔非OSCC恶性肿瘤组治疗疗效差异无统计学意义(P>0.05)。结论血清SCC-Ag对维吾尔族OSCC患者的早期诊断敏感性不高,但在评价治疗疗效,预测肿瘤复发方面有重要的临床意义。
Objective To investigate the expression of squamous cell carcinoma antigen (SCC-Ag) in Uighur oral squamous cell carcinoma (OSCC) patients. Methods Ninety Uighur OSCC patients (OSCC group) and 90 Uighur patients with other oral malignancies (Oral non-OSCC malignant tumor group), 101 Uygur oral benign tumor patients (benign tumor group) and 120 Cases of normal Uighur Uighur normal control group (normal group) serum SCC-Ag levels, and 60 cases of OSCC and 60 cases of oral non-OSCC malignant tumor patients before and after treatment of SCC-Ag levels were analyzed SCC-Ag in OSCC diagnosis and treatment The significance of efficacy. Results The level of SCC-Ag in OSCC group was significantly higher than that in OSCC group (P = 0.002), benign tumor group (P = 0.001) and normal group (P = 0.001). The positive SCC-Ag serogroups of OSCC patients were 43.3% (39/90), significantly higher than the other 3 groups (P = 0.0001). The expression of SCC-Ag in advanced TNM patients with OSCC was higher than that in early stage (P <0.05). There were significant differences in SCC-Ag levels between preoperative and postoperative radiotherapy and chemotherapy in relapsed and non-relapsed patients (P <0.05). There were significant differences in serum SCC-Ag levels between before and after operation and chemoradiotherapy (P <0.01). However, there was no significant difference in the therapeutic effect between oral and non-OSCC malignant tumors (P> 0.05). Conclusion Serum SCC-Ag is not sensitive to the early diagnosis of Uighur OSCC patients, but it has important clinical significance in evaluating therapeutic effect and predicting tumor recurrence.