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对12名志愿者进行丙氟哌酸的药代动力学研究。每人每次口服500mg,一日二次,连续5天。给药后按时留取血及尿液,用微生物法测定药物浓度。在5天的给药过程中,初次与末次给药后其血药浓度相似,无明显蓄积现象;初次给药后的血平均峰浓度2.8±1.3mg/L,达峰时为1.5±0.35小时;末次给药的相应浓度值为2.3±1.1mg/L,达峰时为1.5±0.51小时,两者的药时曲线下的面积相同,半衰期均为2.5小时。初次给药后12小时内尿中排出给药量的27.8±10.5%,而末次剂量后则为42.5±17.6%。实验中还观察了丙氟哌酸对唾液及粪便
Twelve volunteers were enrolled in the pharmacokinetic study of CEF. Each oral 500mg, twice a day for 5 days. Blood and urine were collected on time after administration, and drug concentration was determined by the microbial method. During the course of 5 days of administration, the blood concentration was similar between the first and the last administration, with no obvious accumulation; the mean peak concentration of blood after the initial administration was 2.8 ± 1.3 mg / L, and reached 1.5 ± 0.35 hours at the peak ; The corresponding concentration of the last administration was 2.3 ± 1.1mg / L, peaked at 1.5 ± 0.51 hours, the two under the same drug area curve, half-life were 2.5 hours. Urine excreted a dose of 27.8 ± 10.5% within 12 hours after the first dose, compared with 42.5 ± 17.6% after the last dose. Ciprofloxacin was also tested for saliva and faeces in the experiment