低氧诱导因子1(hypoxia-inducible factor 1,HIF-1)由α和β两个亚基组成,是介导机体缺氧反应的重要转录因子。HIF-1的稳定性和生理活性主要由HIF-1α决定。HIF-1α在变应性炎症反应中具有诱导新生血管形成、调控免疫细胞代谢、保护免疫细胞、支持促炎因子表达及促进免疫细胞黏附等功能。近年研究表明,HIF-1α在变应性气道疾病(哮喘和鼻炎等)发生发展过程中可能发挥着重要作用。 Hypoxia-inducible factor 1 (HIF-1) is composed of two subunits α and β, and is an important transcription factor that mediates the hypoxia response. The stability and physiological activity of HIF-1 are mainly determined by HIF-1α. HIF-1α can induce angiogenesis, regulate immune cell metabolism, protect immune cells, support the expression of proinflammatory cytokines and promote immune cell adhesion in allergic inflammation. Recent studies have shown that HIF-1α may play an important role in the development of allergic airway diseases (such as asthma and rhinitis).