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Coherent optical orthogonal frequency division multiplexing (CO-OFDM) is considered as a key solution for long haul optical fiber communication systems thanks to its high spectral efficiency and robustness against chromatic dispersion. We have investigated a CO-OFDM based on quadrature phase shift keying (QPSK)-OFDM and 16 quadrature amplitude modulation (16QAM)-OFDM over 500 km uncompensated fiber links. The simulation results show that the proposed system is a promising solution to meet the aggregate data rate demands cost effectively in future high-speed optical communication systems.