b型流感杆菌(Hib)荚膜多糖(CPS)共价结合到蛋白质上,产生的偶联物能诱生对CPS和蛋白质组分的依赖T细胞抗体的反应。在注射第1针几种偶联物后,发现大多数1至2月龄的婴儿血清抗体浓度在设定的保护性浓度0.15μg/ml以上。注射第2针后,所有婴儿均在保护浓度以上,但菌苗注射数月到数年后,血清抗体浓度资料报道很少。根据瑞典儿童免疫计划,85名儿童在3、5和12月龄接受3针菌苗注射,此菌苗由Hib The Hib capsular polysaccharide (CPS) is covalently bound to the protein and the resulting conjugate induces T-cell antibody-dependent responses to CPS and protein components. After the injection of several conjugates of the first needles, most of the 1 to 2 month old infant serum antibody concentrations were found to be above the set protective concentration of 0.15 μg / ml. After injection of the second needle, all the infants were above the protective concentration, but the bacterins injected several months to several years later, serum antibody concentration data reported little. According to the Swedish Childhood Immunization Program, 85 children received a 3-dose vaccine injection at 3,5 and 12 months of age and the vaccine consisted of Hib