论文部分内容阅读
RUNX3基因是RUNX转录因子家族成员之一,其在胃黏膜上皮生长调控、脊神经节的神经发育和T细胞分化过程中发挥重要作用。在人类多种恶性肿瘤尤其是胃癌中发现RUNX3基因表达缺失或下调。目前发现有多种机制包括杂合性缺失、高甲基化和点突变等参与了RUNX3基因在胃癌中的表达缺失或下调,其中RUNX3启动子区域CpG岛的甲基化是导致其在胃癌中失活的主要机制。随着研究的不断深入,RUNX3基因有望成为胃癌诊断的一个特异性生物学标志物和基因治疗的靶点。
RUNX3 is a member of the RUNX transcription factor family and plays an important role in the regulation of gastric epithelial growth, neurodevelopment of spinal ganglia and T cell differentiation. RUNX3 gene expression was found to be absent or down-regulated in many human malignancies, especially gastric cancer. A variety of mechanisms have been found, including loss of heterozygosity, hypermethylation and point mutation involved in the expression of RUNX3 gene in gastric cancer, deletion or downregulation, in which RUNX3 promoter CpG island methylation led to its inactivation in gastric cancer The main mechanism. With the deepening of research, RUNX3 gene is expected to become a specific biomarker and gene therapy target for gastric cancer diagnosis.