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目的:观察再程超分割放疗联合高频热疗及毫米波治疗局部复发食管癌近期疗效。方法:38例食管癌放疗后复发患者接受再程超分割放疗联合高频热疗及毫米波治疗,再程放疗采用三维适形超分割,6MV-X线,4~5个共面或非共面适形照射野,每次1.2Gy,每日两次,两次间隔6小时,总剂量DT36~60Gy/3~5周。两次放射治疗期间,采HG-2000Ⅲ体外高频热疗机胸部加温,治疗温度42~45℃,每次持续30分钟,每周2~3次热疗。采用IZL-2003Ⅱ毫米波治疗仪上、下午各1次,每次不低于30分钟,14天1疗程,间隔14天再行第2疗程。结果:38例患者均顺利完成预定治疗计划,治疗后3个月评价近期疗效:CR 8例(21%),PR 25例(65.8%),PD 5例(13%),CR+PR 33例(86.8%)。1年生存率为68.4%。未发生严重毒副反应。结论:再程超分割放疗联合高频热疗及毫米波治疗局部复发食管癌近期疗效明显,无严重毒副反应。值得临床推广应用。
Objective: To observe the short-term curative effect of re-stage hyperfraction radiotherapy combined with high frequency hyperthermia and millimeter wave in the treatment of locally recurrent esophageal cancer. Methods: Thirty-eight patients with esophageal cancer who had relapsed after radiotherapy received re-treatment of hyperfractionated radiotherapy combined with high-frequency hyperthermia and millimeter wave therapy. Radiotherapy was performed with three-dimensional conformal hyperfractionation, 6MV-X, 4-5 coplanar or non- Surface conformal radiation field, each 1.2Gy, twice daily, two intervals of 6 hours, the total dose of DT36 ~ 60Gy / 3 ~ 5 weeks. During the two radiotherapy period, the HG-2000Ⅲ external high frequency hyperthermia machine chest heating, treatment temperature 42 ~ 45 ℃, each time for 30 minutes, 2 to 3 times a week hyperthermia. The use of IZL-2003 Ⅱ millimeter wave therapy apparatus, the afternoon of each 1, each not less than 30 minutes, 14 days and 1 course of treatment, another 14 days after the second course of treatment. Results: All the 38 patients completed the planned treatment successfully. The short-term curative effect was evaluated 3 months after the treatment. CR 8 cases (21%), PR 25 cases (65.8%), PD 5 cases (13%), CR + PR 33 cases (86.8%). One-year survival rate was 68.4%. No serious side effects occurred. Conclusion: Radiotherapy combined with high frequency hyperthermia and millimeter wave in the treatment of locally recurrent esophageal cancer has obvious curative effect in the near future without serious side effects. Worthy of clinical application.