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AIM:To investigate the expression of TFF2 and Helicobacterpyloriinfection in carcinogenesis of gastric mucosa.METHODS:The expression of TFF2 was immunohistochemicallyanalyzed in paraffin-embedded samples from 119 patientswith endoscopic biopsy and subtotal gastrectomy specimensof gastric mucosal lesions,including 16 cases of chronicsuperficial gastritis (CSG),20 chronic atrophic gastritis (CAG),35 intestinal metaplasia (IM),23 gastric epithelial dysplasia(GED) and 25 gastric carcinoma (CA),and Helicobacter pyloriinfection was detected by Warthin-Starry staining.RESULTS:1:TFF2 was located in the cytoplasm of gastricmucous neck cell.The expression of TFF2 was 100 %,100 %,0,56.5 % and 0 in CSGs,CAGs,IMs,GEDs andCAs,respectively.2:The value of TFF2 positive cell densityin CSG with Helicobacter pylori infection was higher thanthat without Helicobacter pylori infection.(52.89±7.27 vs46.49±13.04,P>0.05);But the value of TFF2 positive celldensity in CAG and GED with Helicobacter pylori infectionwas significantly lower than that without Helicobacterpyloriinfection (18.17±4.09 vs 37.93±13.80,P<0.01 and14.44±9.32 vs 24.84±10.22,P<0.05).CONCLUSION:Increase of TFF2 expression in CSG isperhaps associated with the protective mechanism aftergastric mucosal injury.Decrease of TFF2 expression in CAGpossibly attributes to the decrease in the number of gastricgland cell expressing TFF2.Re-expression of TFF2 in gastricepithelial dysplasia implies that TFF2 possibly contributes tothe initiation of gastric carcinoma.The effect of Helicobacterpylorion the expression of TFF2 depends on the status ofgastric mucosa.
AIM: To investigate the expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. METHODS: The expression of TFF2 was immunohistochemicallyalyzed in paraffin-embedded samples from 119 patients with endoscopic biopsy and subtotal gastrectomy specimens of gastric mucosal lesions, including 16 cases of chronicsuperficial gastritis (CSG ), 20 chronic atrophic gastritis (CAG), 35 intestinal metaplasia (IM), 23 gastric epithelial dysplasia (GED) and 25 gastric carcinoma (CA), and Helicobacter pylori infection was detected by Warthin-Starry staining. in the cytoplasm of gastric mucus neck cell. The expression of TFF2 was 100%, 100%, 0,56.5% and 0 in CSGs, CAGs, IMs, GEDs andCAs, respectively.2: The value of TFF2 positive cell density in CSG with Helicobacter pylori (52.89 ± 7.27 vs46.49 ± 13.04, P> 0.05); But the value of TFF2 positive cell density in CAG and GED with Helicobacter pylori infec tion was significantly lower than that without Helicobacter pylori infection (18.17 ± 4.09 vs 37.93 ± 13.80, P <0.01 and 14.44 ± 9.32 vs 24.84 ± 10.22, P <0.05) .CONCLUSION: Increase of TFF2 expression in CSG isperhaps associated with the protective mechanism aftergastric mucosal injury.Decrease of TFF2 expression in CAGpossibly attributes to the decrease in the number of gastricgland cell expressing TFF2.Re-expression of TFF2 in gastricepithelial dysplasia implies that TFF2 may contributes tothe initiation of gastric carcinoma. The effect of Helicobacter pylorion the expression of TFF2 depends on the status ofgastric mucosa.