核转录因子κB(nuclear facter of kappa B,NFκ-B)作为一种分布广泛的真核细胞转录因子,能与B细胞免疫球蛋白轻链基因的增强子κB序列特异性结合,参与调控多种与细胞凋亡、肿瘤形成和转移有关的基因表达。近年,NF-κB在肾肿瘤发生、发展、治疗中的作用及其机制逐渐成为医学研 As a widely distributed eukaryotic transcription factor, nuclear facter of kappa B (NF-κB) binds specifically to the enhancer κB sequence of the B cell immunoglobulin light chain gene and is involved in the regulation of multiple Gene expression related to apoptosis, tumor formation and metastasis. In recent years, the role of NF-κB in the occurrence, development and treatment of renal tumors and its mechanism have gradually become medical research