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化学学科发展至今拥有极强的能力来获得高的合成效率,但是在多肽合成中“困难序列”的存在仍然成为成功缩合的巨大挑战。本文综述了影响多肽缩合效率的因素以及提高“困难序列”缩合效率的有效方法。所述方法均简便易行,适用于多肽的固相合成或液相合成。
The chemistry discipline so far has a strong ability to achieve high synthetic efficiency, but the presence of “difficult sequences” in polypeptide synthesis remains a huge challenge for successful condensation. This review summarizes the factors that affect the efficiency of peptide condensation and the effective ways to improve the efficiency of the “difficult sequence” condensation. The methods are simple and convenient, suitable for the solid phase synthesis of peptides or liquid phase synthesis.