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目的研制一种检测心肌生物力学属性的介入超声硬度检测仪,可直接、定量检测活体心肌组织硬度,为心肌病变提供力学相关资料。方法仪器由介入超声硬度检测导管、生理信号单元和主机组成。检测时,在X线透视下,将导管通过犬外周动脉血管进入左心室,印压左室壁,超声检测心肌厚度形变值,压力传感器获得印压力值,根据应力-应变关系,计算得到表征组织硬度的参量。结果应用该仪器进行活体犬心肌硬度检测,成功获取了舒张末期左室心尖部和游离壁心肌硬度值,其值分别为(40.55±4.75)kPa、(36.02±7.03)kPa。结论该仪器为直接定量检测活体心肌硬度提供了方法,可为临床判断心脏的整体和局部舒张、收缩功能异常提供定量检测技术,同时,也可检测其他深部组织硬度改变。
Objective To develop an interventional ultrasonic hardness tester for detecting the biomechanical properties of myocardium, which can directly and quantitatively detect the hardness of living myocardium and provide mechanics-related information for myocardial lesion. Methods Instrument interventional ultrasound hardness detection catheter, physiological signal unit and the host. At the time of X-ray examination, the catheter was infiltrated into the left ventricle and the left ventricular wall through the canine peripheral artery. The thickness of the myocardium was measured by ultrasound. The pressure value was obtained by the pressure sensor. According to the stress-strain relationship, Hardness parameters. Results The myocardial stiffness of live dogs was detected by this instrument, and the myocardial stiffness values of left ventricular apex and free wall were obtained successfully. Their values were (40.55 ± 4.75) kPa and (36.02 ± 7.03) kPa, respectively. Conclusion The instrument provides a direct method for the quantitative determination of myocardial stiffness in vivo. It can provide quantitative detection of global and regional diastolic and systolic dysfunction in clinical diagnosis. At the same time, it can also detect the changes of hardness in other deep tissues.