胸主动脉瘤(TAA)是累及主动脉壁的致命性疾病。目前,TAA的发病机制尚不完全清楚,可能存在遗传及环境因素的共同作用,同时通过血流动力学变化、透壁炎症反应及细胞外基质降解和重构等机制,引起动脉弹性和胶原蛋白破坏,导致主动脉壁变薄并向外膨胀及动脉瘤形成。本文综述TAA分子发病机制的研究进展。 Thoracic Aneurysm (TAA) is a fatal disease involving the aortic wall. At present, the pathogenesis of TAA is not yet fully understood, there may be a combination of genetic and environmental factors, and at the same time through the hemodynamic changes, transmural inflammation and extracellular matrix degradation and remodeling and other mechanisms, causing arterial elasticity and collagen Damage, leading to aortic wall thinning and outward expansion and aneurysm formation. This review summarizes the research progress of TAA molecular pathogenesis.