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目的探讨粉尘螨滴剂舌下含服对儿童咳嗽变异性哮喘的疗效及安全性。方法回顾2015年10月-2016年10月到泸州市人民医院诊治的咳嗽变异性哮喘患儿120例,按照随机原则分为对照组和观察组各60例,对照组患儿给予哮喘规范化治疗,观察组患儿在此基础上配合粉尘螨滴剂舌下含服,比较两组患儿疗效和不良反应发生情况。结果治疗前两组患儿各项指标均未表现出明显差异(P>0.05);治疗后观察组患儿Ch-CACT评分、PEF实测值/预计值、血清IFN-γ水平、嗜酸性粒细胞比例下降值、治疗总有效率均明显高于对照组患儿,差异有统计学意义(P<0.05);日、夜间症状评分、症状开始改善时间、血清IL-4水平均明显低于对照组患儿,差异有统计学意义(P<0.05);观察组部分患儿出现皮肤瘙痒、流涕、喷嚏等不良反应,抗过敏处理后均得以有效缓解。结论粉尘螨滴剂舌下含服对儿童咳嗽变异性哮喘疗效确切,安全性高,能够有效调节免疫功能,改善患儿临床症状。
Objective To investigate the efficacy and safety of subcutaneous dust mite drops on children with cough variant asthma. Methods 120 patients with cough variant asthma diagnosed and treated in Luzhou People’s Hospital from October 2015 to October 2016 were divided into control group and observation group according to the randomized principle of 60 cases, control group of children given asthma normalized treatment, On the basis of this, children in the observation group cooperated with the drops of dust mite to sublingual, and compared the curative effect and adverse reactions of the two groups of children. Results There was no significant difference between the two groups before treatment (P> 0.05). After treatment, the Ch-CACT score, PEF measured value / predicted value, serum IFN-γ level, eosinophil (P <0.05). The score of day and night symptom, the time of symptom onset and the level of IL-4 in serum were significantly lower than those in control group The difference was statistically significant (P <0.05). Some patients in the observation group had skin pruritus, runny nose, sneeze and other adverse reactions, which were effectively relieved after anti-allergy treatment. Conclusion Dust mites drops oral sublingual suppressive effect on children with cough variant asthma, high safety, can effectively regulate immune function and improve clinical symptoms in children.