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Objective:To investigate the gastroprotective activity of hydroalcoholic extract leaves of Ficus religiosa(F.religiosa) in different experimental models of gastric ulcer in rats.Methods:The hydroalcoholic extract leaves of F.religiosa were studied at two dose levels(250 and 500 mg/ kg,oral) in rats against absolute ethanol(0.2 mL oral),aspirin(200 mg/kg) and pyloric ligation induced gastric ulcer.Ranitidine(50 mg/kg,oral) was used as a standard drug.Mean ulcer indices and oxidative stress were measured.Phytochemical tests and acute toxicity tests were also carried out.Results:Administration of F.religiosa to rats significantly decreased the ulcer index value when compared with the control treated group.Ranitidine(50 mg/kg,oral) also produced a significant decrease the ulcer index value when compared with the control treated group.Phytochemical analysis revealed the presence of tannins,sterols,saponins,flavonoids, carbohydrates and proteins.Conclusions:The results suggest that the leaves of the F.religiosa possess significant anti ulcer activity.
Objective: To investigate the gastroprotective activity of hydroalcoholic extract leaves of Ficus religiosa (F. religiosa) in different experimental models of gastric ulcer in rats. Methods: The hydroalcoholic extract leaves of F. religiosa were studied at two dose levels (250 and 500 mg / kg, oral) in rats against absolute ethanol (0.2 mL oral) aspirin (200 mg / kg) and pyloric ligation induced gastric ulcer. Ranitidine (50 mg / kg, oral) was used as a standard drug oxidative stress were measured. Phytochemical tests and acute toxicity tests were also carried out. Results: Administration of F. religiosa to rats significantly decreased the ulcer index value when compared with the control treated group. Ranitidine (50 mg / kg, oral) also produced a significant decrease the ulcer index value when compared with the control treated group. Phytochemical analysis revealed the presence of tannins, sterols, saponins, flavonoids, carbohydrates and proteins. Conclusions: The results suggest that the leave s of the F.religiosa possess significant anti ulcer activity.