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目的探讨胃泌素受体（ｇａｓｔｒｉｎｒｅｃｅｐｔｏｒ，ＧＲ）在胃癌自分泌生长中的作用及其与胃癌预后的关系。方法应用胃泌素受体的放射配基结合分析法，测定３４例胃癌组织胃泌素受体的含量及其亲和力。结果３４例胃癌中，胃癌组织胃泌素受体阳性１６例，其中低亲和力胃泌素受体２例；高亲和力胃泌素受体１４例，高含量胃泌素受体９例，低含量胃泌素受体５例。２４例Ⅲ、Ⅳ期胃癌中，胃癌组织胃泌素受体阳性１５例；１０例Ⅰ、Ⅱ期胃癌中，胃癌组织胃泌素受体阳性仅１例。胃癌组织胃泌素受体的表达与胃癌临床病理分型无关。胃泌素受体阳性的胃癌细胞Ｓ期细胞比例及超５倍体细胞比例均高于胃泌素受体阴性者。对３１例胃癌患者随访３１～６９个月，胃泌素受体阴性或低亲和力胃泌素受体的胃癌患者，其预后较高亲和力胃泌素受体者好。结论胃泌素受体易于在晚期胃癌中表达，其对评估胃癌患者的预后有一定参考价值。
Objective To investigate the role of gastrin receptor (GR) in the autocrine growth of gastric cancer and its relationship with the prognosis of gastric cancer. Methods Gastrin receptors were detected by radioligand binding assay to determine gastrin receptor content and its affinity in 34 patients with gastric cancer. Results Gastrin receptor was positive in 16 cases of gastric cancer and gastrin receptor in 16 cases, including 2 cases of low affinity gastrin receptor; 14 cases of high affinity gastrin receptor, 9 cases of high gastrin receptor, low content Gastrin receptor in 5 cases. In 24 cases of stage III and IV gastric cancers, gastrin receptors were positive in 15 cases; in 10 cases of stage I and II gastric cancers, gastrin receptors were positive in only one case. The expression of gastrin receptor in gastric cancer has nothing to do with the clinicopathological classification of gastric cancer. The proportion of S-phase cells and the proportion of hyper-5-fold somatic cells in gastrin receptor-positive gastric cancer cells were higher than those with gastrin receptor-negative. A follow-up of 31 to 69 months in 31 patients with gastric cancer, with gastrin receptor-negative or low-affinity gastrin receptors in gastric cancer patients, was associated with a better prognosis for gastrin receptors. Conclusion Gastrin receptor is easy to be expressed in advanced gastric cancer. It has certain reference value for evaluating the prognosis of gastric cancer patients.