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阿斯匹林可引起胎鼠发育迟缓,产生皮肤血斑和神经管缺损(NTD)等致畸作用。甘氨酸可降低其致畸率。维生素可以降低人群调查和实验动物的NTD的发生率。本文报告维生素与甘氨酸合并应用,对阿斯匹林致畸的预防效应。
Aspirin can cause fetal rat retardation, resulting in skin blood spots and neural tube defects (NTD) and other teratogenic effects. Glycine reduces its teratogenicity. Vitamins reduce the incidence of NTD in population surveys and laboratory animals. This article reports the combined effects of vitamin and glycine on the prevention of teratogenic effects of aspirin.