目的探讨子宫内膜机械刺激改善子宫内膜容受性对临床妊娠率、胚胎着床率和活产率的影响。方法对进入周期患者在月经3-5天采用一次性宫腔组织吸引管进行宫内膜刺激,刺激宫内膜476个移植周期,对照组未刺激为471个移植周期。结果内膜刺激组移植胚胎数1238个,共着床193个,着床率为15.6%,临床妊娠率为32.6%(155/476),活产率达62.6%(97/155);对照组移植胚胎数1191个,着床166个,着床率为13.9%,临床妊娠率为30.8%(145/471),活产率为49.0%。内膜刺激组与对照组在胚胎着床率和临床妊娠率之间无显著差异(P>0.05),但有升高的趋势;而内膜刺激显著提高了活产率(P<0.05)。结论机械刺激子宫内膜对IVF-ET周期胚胎着床率和临床妊娠率有所提高,能显著提高活产率。 Objective To investigate the effect of endometrial mechanical stimulation on endometrial receptivity on clinical pregnancy rate, embryo implantation rate and live birth rate. Methods The endometrial stimulation was performed in one-time uterine tissue suction tube 3-5 days after menstruation in patients entering the cycle. 476 transplant cycles were stimulated in the endometrium and 471 in the control group. Results The number of embryo transferred in the endomembrane group was 1238, with a total of 193 implants, the implantation rate was 15.6%, the clinical pregnancy rate was 32.6% (155/476) and the live birth rate was 62.6% (97/155). The control group The number of embryos transferred was 1191, with 166 implants. The implantation rate was 13.9%. The clinical pregnancy rate was 30.8% (145/471). The live birth rate was 49.0%. There was no significant difference between the endometrial stimulation group and the control group in the embryo implantation rate and clinical pregnancy rate (P> 0.05), but there was an increasing trend; while the intimal stimulation significantly increased the live birth rate (P <0.05). Conclusions Mechanical stimulation of endometrium improves IVF-ET embryo implantation rate and clinical pregnancy rate, which can significantly increase the live birth rate.