用微电极细胞内记录终板电位（ＥＰＰ）的电生理学方法，在２０只成年蟾蜍的坐骨神经－缝匠肌标本上研究了雷公藤多甙（ＴＷＰ）对神经肌接头（ＮＭＪ）兴奋传递的影响。结果表明：ＴＷＰ可引起ＥＰＰ振幅改变，影响ＮＭＪ的兴奋传递，而且其影响具有明显的量效依赖关系，适当浓度的ＴＷＰ能明显地增加ＥＰＰ振幅，促进ＮＭＪ的兴奋传递。 The effect of triptolide (TWP) on the neuromuscular junction (NMJ) excitatory transmission was studied in 20 adult sciatic nerve-sartorial muscles using electrophysiological recordings of end-plate potential (EPP) in intracellular microelectrodes. . The results showed that TWP can cause changes in EPP amplitude, affect the excitatory transmission of NMJ, and its effect has a significant dose-effect dependence. Appropriate concentration of TWP can significantly increase the amplitude of EPP and promote the excitatory transmission of NMJ.