【摘 要】
：
Treatments of atherogenesis,one of the most common cardiovascular diseases (CVD),are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty (PTCA),the most revolutionary medica
【机 构】
：
Key Laboratory of Advanced Technology for Materials of the Education Ministry,School of Materials Sc
论文部分内容阅读
Treatments of atherogenesis,one of the most common cardiovascular diseases (CVD),are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty (PTCA),the most revolutionary medical procedure used for vascular restoration.Combined with an expanding balloon,vascular stents used at stricture sites enable the long-time restora-tion of vascular permeability.However,complication after stenting,in-stent restenosis (ISR),hinders the advancement of vascular stents and are associated with high medical costs for patients for decades years.Thus,the development of a high biocompatibility stent with improved safety and efficiency is urgently needed.This review provides an overview of current advances and potential technologies for the modi-fication of stents for better treatment and prevention of ISR.In particular,the mechanisms of in-stent restenosis are investigated and summarized with the aim to comprehensively understanding the patho-genesis of stent complications.Then,according to different therapeutic functions,the current stent mod-ification strategies are reviewed,including polymeric drug eluting stents,biological friendly stents,pro-healing stents,and gene stents.Finally,the review provides an outlook of the challenges in the design of stents with optimal properties.Therefore,this review is a valuable and practical guideline for the devel-opment of cardiovascular stents.
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