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选择240例2型糖尿病作为研究对象,随机选择同期120例健康体检者作为对照对象,空腹状态下抽取静脉血,糖化血红蛋白测定采用高效液相色谱法;FT3、FT4、TT3、TT4及TSH采用放射免疫分析法测定。结果 2型糖尿病患者入院时T3、FT3低于健康体检组(P<0.05),T3、FT3低于正常水平40例(16.67%、40/240);低T3、FT3组糖化血红蛋白(8.87±1.03)%、存在并发症85.00%均高于甲状腺激素水平正常组的(7.59±0.89)%、72.00%(P<0.05);2型糖尿病患者好转出院时T3、FT3均高于入院水平(P<0.05)。结论 2型糖尿病患者存在一定程度的甲状腺激素异常,甲状腺激素可作为判断2型糖尿病患者病情程度的指标之一,须积极评价患者甲状腺功能,及时发现甲状腺激素异常,T3低下患者适当给予小剂量左甲状腺素药物进行治疗。
240 cases of type 2 diabetes mellitus were selected as study subjects, 120 healthy subjects were randomly selected as the control subjects, venous blood was drawn under fasting condition, and HbAlc was determined by high performance liquid chromatography. FT3, FT4, TT3, TT4 and TSH Immunoassay Determination. Results T3, FT3 in type 2 diabetic patients were lower than those in healthy subjects (P <0.05), T3 and FT3 were lower than normal in 40 patients (16.67%, 40/240), and low T3 and FT3 in patients with T2DM were 8.87 ± 1.03 ), And 85.00% of complications were higher than that of normal thyroid hormone group (7.59 ± 0.89)%, 72.00% (P <0.05) 0.05). Conclusions There is a certain degree of thyroid hormone abnormality in patients with type 2 diabetes. Thyroid hormone can be used as an indicator of the severity of type 2 diabetes. Positive thyroid function should be evaluated and thyroid hormone abnormalities detected in time. Low dose left Thyroid hormone drugs for treatment.