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目的:观察间断性肾脏替代(IRRT)治疗重症急性胰腺炎(SAP)的临床疗效。方法:回顾分析21例进行采用间断血液滤过治疗的SAP患者的疗效,就其治疗前后的血压、心率等情况进行密切观察,并检测肝肾功能、电解质、血常规等,最后进行APACHEⅡ评分。结果:21例SAP患者,死亡3例,存活18例,死亡率为14.3%。经IRRT治疗后,APACHEⅡ评分明显下降(P<0.05),生命体征明显好转;生化指标明显改善(P<0.05)。结论:早期合理应用IRRT,可以清除炎症介质,维持内环境稳定,改善脏器功能,提高疗效。早期常规综合治疗SAP的同时合理应用IRRT,可为临床P提供重要的辅助手段。
Objective: To observe the clinical efficacy of intermittent renal replacement therapy (IRRT) in the treatment of severe acute pancreatitis (SAP). Methods: A retrospective analysis of 21 patients treated with intermittent hemofiltration in patients with SAP, the treatment of blood pressure before and after the heart rate were closely observed, and liver and kidney function, electrolytes, blood routine, and finally APACHE Ⅱ score. Results: In 21 SAP patients, 3 died and 18 survived, with a mortality rate of 14.3%. After IRRT treatment, APACHE Ⅱ score decreased significantly (P <0.05), vital signs improved significantly; biochemical index improved significantly (P <0.05). Conclusion: Early rational use of IRRT can clear inflammatory mediators, maintain stable internal environment, improve organ function and improve curative effect. Routine conventional comprehensive treatment of SAP while the rational use of IRRT, can provide an important clinical P ancillary tools.