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目的:研究复方α-酮酸对维持性血液透析(MHD)患者营养及脂质代谢的影响。方法:将40例MHD患者随机分为两组:(1)实验组(n=20),予常规蛋白饮食,并服用复方α-酮酸12片/d(;2)对照组(n=20),予常规蛋白饮食,不服用复方α-酮酸。分别于治疗前、治疗后3个月后测定各项血生化指标及人体测量学指标。结果:经3个月治疗后,实验组血白蛋白、前白蛋白较前明显升高(P<0.01),总胆固醇和甘油三酯明显下降(P<0.01),血红蛋白无明显变化(P>0.05);对照组血红蛋白、血白蛋白、前白蛋白及血脂无明显变化;实验组及对照组治疗前后体重指数、肱三头肌皮褶厚度、上臂肌围无明显变化(P>0.05)。结论:复方α-酮酸可有效改善维持性血液透析患者营养状况以及脂质代谢,但长期使用该疗法的疗效和安全性有待于进一步的研究。
Objective: To study the effects of a-α-keto acid on nutrition and lipid metabolism in maintenance hemodialysis (MHD) patients. Methods: Forty patients with MHD were randomly divided into two groups: (1) experimental group (n = 20), conventional protein diet and 12-day compound of α-keto acid ), To conventional protein diet, do not take compound α-keto acid. Respectively before treatment, after treatment 3 months after the determination of blood biochemical indicators and anthropometric indicators. Results: After three months of treatment, serum albumin and prealbumin in the experimental group were significantly increased (P <0.01), total cholesterol and triglyceride were significantly decreased (P <0.01), hemoglobin did not change significantly (P> 0.05). There was no significant change in hemoglobin, serum albumin, prealbumin and blood lipids in the control group. There was no significant change in body mass index, triceps skinfold thickness and muscularis propria arm before and after treatment in the experimental group and the control group (P> 0.05). Conclusion: Compound α-keto acid can effectively improve nutritional status and lipid metabolism in maintenance hemodialysis patients, but the long-term use of the efficacy and safety of the treatment remains to be further studied.