目的观察吸莫合烟对金黄色地鼠肺组织超微结构的影响。方法取肺组织做超薄切片，用透射电镜观察。结果Ⅰ型肺泡细胞和毛细血管内皮细胞均肿胀，线粒体亦肿胀，嵴排列紊乱、断裂消失。Ⅱ型肺泡细胞线粒体体积缩小，板层小体空泡变、胞膜破裂，细胞器溢出。肺泡巨噬细胞次级溶酶体明显增多。结论吸莫合烟可造成金黄色地鼠肺组织结构的改变，进而影响气体交换的功能。 Objective To observe the effects of smoking alopecia smoke on the ultrastructure of lung tissue in golden hamster. Methods Take the lung tissue to make ultrathin sections and observe with transmission electron microscope. Results Type I alveolar cells and capillary endothelial cells were swollen, mitochondria also swollen, ridge arranged disorder, rupture disappeared. Ⅱ type alveolar cells mitochondrial volume reduction, lamellar body vacuoles, membrane rupture, organelle overflow. Alveolar macrophages secondary lysosomes increased significantly. Conclusion Fuming Mo smoke can cause golden hamster lung tissue structure changes, thus affecting the function of gas exchange.