论文部分内容阅读
目的观察促性腺激素释放激素激动剂(GnRHa)联合曼月乐(左炔诺孕酮宫内节育系统)治疗子宫内膜重度不典型增生的临床效果。方法选取在该院治疗的子宫内膜重度不典型增生患者共124例,随机分为治疗组与对照组各62例,对照组给予GnRHa,治疗组予GnRHa+曼月乐治疗,比较2组临床疗效和空腹血糖(FPG)、24h尿蛋白排泄率(UAER)、平均血压(MAP)、尿素氮(BUN)以及血肌酐(Scr)等水平。结果治疗组总有效率为98.39%高于对照组的88.71%,差异有统计学意义(P<0.05);治疗组FPG、UAER、MAP、BUN、Scr水平均显著低于对照组,差异均有统计学意义(P<0.05)。结论 GnRHa联合曼月乐治疗子宫内膜重度不典型增生患者,显著提高患者临床疗效,具有临床使用价值。
Objective To observe the clinical effect of GnRHa combined with Mirena (levonorgestrel intrauterine system) in the treatment of severe dysplasia of endometrium. Methods A total of 124 patients with severe atypical hyperplasia of endometrium treated in this hospital were randomly divided into treatment group (n = 62) and control group (n = 62). GnRHa was given to the control group and GnRHa plus Mirena was given to the treatment group. The clinical efficacy was compared between the two groups FPG, UAER, MAP, BUN, and Scr in serum were measured. Results The total effective rate in the treatment group was 98.39%, which was significantly higher than that in the control group (88.71%, P <0.05). The levels of FPG, UAER, MAP, BUN and Scr in the treatment group were significantly lower than those in the control group Statistical significance (P <0.05). Conclusion GnRHa combined with Mirena music treatment of patients with severe atypical hyperplasia of endometrium, significantly improve the clinical efficacy of patients with clinical value.