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已知银杏叶提取物具有改善脑功能障碍的作用。在筛选银杏叶显示中枢作用的成分时,将倍半萜白果内酯(BB)给予小鼠,明确了对药物诱发痉挛与电击痉挛的抑制作用。本次为了观察BB的抗痉挛作用与GABA神经系的相关性,探讨了BB对小鼠脑内GABA浓度的影响。
Ginkgo biloba extract is known to have an effect of improving brain dysfunction. When screening Ginkgo biloba leaves showed a central component, sesquiterpene bilobalide (BB) was administered to mice, and the inhibitory effect on drug-induced and electrokinetic licking was clarified. In order to observe the anti-spasm effect of BB and the correlation of GABA nervous system, the effect of BB on GABA concentration in mouse brain was investigated.