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目的:通过检测肌瘤组织中VEGF及雌激素受体表达情况,阐释其之间的联系,从而揭示子宫肌瘤潜在的发生机制,为临床治疗提供理论依据。方法:采用SP免疫组织化学方法测定肌瘤组织及邻近子宫正常平滑肌组织中VEGF及雌激素受体(ER)表达情况。结果:子宫肌瘤患者的肌瘤组织中VEGF表达强度高于肌瘤周围正常子宫平滑肌组织,差异具显著性(P<0.05);子宫肌瘤患者的肌瘤组织中雌激素受体表达强度高于肌瘤周围正常子宫平滑肌组织,差异具显著性(P<0.05);通过相关性分析,我们发现在肌瘤组织中,VEGF与雌激素受体具相关性,且呈正相关(r=0.301,P<0.05)。结论:VEGF可能通过促进ER表达,从而参与子宫肌瘤的发生发展。雌激素可能通过促进VEGF表达,促进子宫肌瘤生长。
Objective: To detect the expression of VEGF and estrogen receptor in myoma and to elucidate the relationship between them, so as to reveal the underlying mechanism of uterine fibroids and provide a theoretical basis for clinical treatment. Methods: SP immunohistochemistry was used to determine the expression of VEGF and estrogen receptor (ER) in myometrium and adjacent uterine smooth muscle. Results: The expression of VEGF in myoma of uterine fibroids was higher than that in normal uterine smooth muscle of myoma (P <0.05). The expression of estrogen receptor in myoma of uterine fibroids was high There was a significant difference in the normal uterine smooth muscle tissue around the fibroids (P <0.05). Correlation analysis showed that there was a positive correlation between VEGF and estrogen receptor in fibroids (r = 0.301, P <0.05). Conclusion: VEGF may participate in the development of uterine fibroids by promoting the expression of ER. Estrogen may promote the growth of uterine fibroids by promoting the expression of VEGF.