1983年开始报道出血性休克脑病综合征,主要见于健康婴儿在轻微前驱症状后,骤然发生严重的循环休克、意识障碍和惊厥。实验室检查有凝血功能障碍。死亡率高,存活患儿常伴脑损害。尽管这种疾病在临床中较常见,德国迄今仅报道4例。因此,HESE 患儿可能常被误诊。通过完善的实验室检查和其他特检可作出诊断。出血性休克脑病综合征的提出对继续降低围产期后婴儿死亡率 Hemorrhagic shock encephalopathy syndrome was first reported in 1983, mainly in the sudden onset of severe circulatory shock, disturbance of consciousness and convulsions in healthy infants after mild prodromal symptoms. Laboratory tests have coagulation disorders. High mortality, children often survive with brain damage. Although the disease is more common in clinical practice, only 4 cases have been reported in Germany so far. Therefore, children with HESE may be misdiagnosed. Through the perfect laboratory tests and other special inspection can make a diagnosis. The proposed hemorrhagic shock encephalopathy syndrome continues to reduce infant mortality after perinatal period