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目的:探讨米非司酮治疗稽留流产的临床有效剂量。方法:将60例诊断为稽留流产患者随机分成两组,A组米非司酮每次25mg,早晚各1次,共服3天,总量150mg;第4天服米索前列醇600ug。B组米非司酮每次50mg,总量300mg,其余同A组。结果:A、B两组治愈率分别为53.33％、90％;不全流产率分别为30％、10％、差异有高度显著性(P<0.01)。药流后阴道出血时间超过14天者行清宫术,病理检查为变性绒毛或滋养细胞并炎症细胞浸润。结论:(1)米非司酮总量达300mg时,治疗稽留流产疗效可靠、安全。(2)药流后阴道出血时间长与绒毛或滋养细胞残留有关,应及时清宫并加用抗生素。
Objective: To investigate the clinical effective dose of mifepristone in treating missed abortion. Methods: Sixty patients diagnosed as missed abortion were randomly divided into two groups. Group A received mifepristone 25mg once daily for 3 days for a total of 150mg. On the 4th day, misoprostol 600ug was given. Group B mifepristone 50mg, total 300mg, the rest with the A group. Results: The cure rates of group A and group B were 53.33% and 90% respectively. The rate of incomplete abortion was 30% and 10%, respectively. The difference was highly significant (P <0.01). After medical abortion vaginal bleeding more than 14 days were cured curettage, pathological examination of degenerative villi or trophoblastic and inflammatory cell infiltration. Conclusion: (1) When the total amount of mifepristone 300mg, the treatment of missed abortion is reliable and safe. (2) vaginal bleeding after a long time with villi or trophoblast cells related, timely clearance and add antibiotics.