目的探讨老年患者蒽环类药物急性心脏毒性的防治。方法 42例分为治疗组22例,对照组20例;THP剂量50 mg/m2,分2 d静脉滴注,治疗组加用参麦注射液1周。结果治疗组和对照组有效率分别为55.4%和55.6%,两组比较差异无统计学意义。化疗后出现心电图异常8例,对照组6例,治疗组2例,均为一过性改变,无Ⅲ级以上心脏毒性发生。结论吡喃阿霉素分次静脉滴注化疗配合中药参麦注射液,可减低老年患者的急性心脏毒性。 Objective To investigate the prevention and treatment of anthracycline acute cardiotoxicity in elderly patients. Methods Forty-two patients were divided into treatment group (n = 22) and control group (n = 20). THP was given at a dose of 50 mg / m2 intravenously for 2 days. The treatment group was given Shenmai injection for 1 week. Results The effective rates of the treatment group and the control group were 55.4% and 55.6% respectively, with no significant difference between the two groups. Electrocardiogram abnormalities occurred after chemotherapy in 8 cases, 6 cases in the control group and 2 cases in the treatment group. All of them were transient changes, and no grade III cardiotoxicity occurred. Conclusion Pyridium doxorubicin sub-divided intravenous chemotherapy with traditional Chinese medicine Shenmai injection can reduce the elderly patients with acute cardiotoxicity.