目的 :探讨肾病综合征并急性肾功能衰竭的临床特征和病理变化及其与预后的关系。方法 :对 3 0例肾病综合征并急性肾功能衰竭病例进行分析 ,肾穿刺活检。结果 :病理学上肾小球主要表现为肾小球轻微病变的有 17例 ,2例为局灶节段性硬化 ,4例为膜增殖性肾炎 ,2例为重度系膜增生性肾炎 ,2例为早期膜性肾病 ,1例为慢性肾小管、间质炎。所有病例均伴有不同程度的肾小管、间质损害。 17例治愈 ,5例有效 ,6例无效 ,2例死亡。结论 :肾脏组织学损伤的类型和程度与肾病综合征的疗效和预后有关 ,对激素治疗不敏感的患者 ,应及早行肾活检 ,以指导治疗 Objective: To investigate the clinical features and pathological changes of nephrotic syndrome with acute renal failure and its relationship with prognosis. Methods: Thirty cases of nephrotic syndrome with acute renal failure were analyzed, and renal biopsy was performed. Results: The main pathological glomeruli showed glomerular minor lesions in 17 cases, 2 cases of focal segmental sclerosis, 4 cases of membranoproliferative glomerulonephritis, 2 cases of severe mesangial proliferative glomerulonephritis, 2 An example of early membranous nephropathy, a case of chronic tubular, interstitial. All cases were associated with varying degrees of tubulointerstitial damage. Seventeen were cured, five were effective, six were ineffective, and two died. Conclusion: The type and degree of renal histological injury are related to the curative effect and prognosis of nephrotic syndrome. Patients who are not sensitive to hormone therapy should undergo renal biopsy as early as possible to guide treatment