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目的：观察地尔硫对冠心病病人的抗脂质过氧化及抗氧自由基作用。方法：冠心病病人３０例为治疗组（男性２１例，女性９例，年龄５８±ｓ６ａ），给予地尔硫３０ｍｇ，ｐｏ，ｔｉｄ，共４ｗｋ。健康人组３０例（男性１８例，女性１２例，年龄５８±９ａ）。结果：治疗组在给药前较健康人组的血清ｏｘＬＤＬ，ＬＰＯ，ＳＣＬ，ＬＣＬ值显著升高，Ｐ＜０．０１，ＧＳＨ－Ｐｘ显著降低，Ｐ＜０．０１，ＳＯＤ活力两者无明显差异，Ｐ＞０．０５。治疗组用药后与用药前相比ｏｘＬＤＬ，ＬＰＯ，ＳＣＬ，ＬＣＬ值显著下降，Ｐ＜０．０１或＜０．０５，ＧＳＨ－Ｐｘ显著升高，Ｐ＜０．０１，治疗组治疗后与健康人组相比，除ＬＣＬ外，其他指标皆无明显差异，Ｐ＞０．０５。结论：地尔硫是一良好的抗氧化剂。
Objective: To observe the effect of diltiazem on anti-lipid peroxidation and antioxidant free radical in patients with coronary heart disease. Methods: Thirty patients with coronary heart disease were treated (21 males and 9 females, age 58 ± s6a). Diltiazem was administered 30 mg, po, tid for 4 weeks. 30 healthy subjects (18 males and 12 females, age 58 ± 9 years). Results: Before treatment, the serum oxLDL, LPO, SCL and LCL values in the treatment group were significantly increased, P <0.01, GSH-Px significantly decreased, P <0.01, SOD activity was not significantly Difference, P> 0.05. After treatment, the levels of oxLDL, LPO, SCL and LCL in the treatment group decreased significantly compared with that before treatment (P <0.01 or <0.05), GSH-Px increased significantly Compared with other groups, there was no significant difference in other indexes except LCL, P> 0.05. Conclusion: Diltiazem is a good antioxidant.