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Mccarthy T et al.Drug Intell and Clin Pharm 1986;20(3):199 偏头痛的确切发病机理迄今不明。有人认为是某种尚未查清的物质突然引起的一系列生理现象,如血小板凝集、五羟色胺和血栓烷A_2的释出,前列腺素的激化,导致局部脑血管收缩和无菌炎症,继之以反应性的脑血管扩张,因而可使疼痛敏感的小动脉发生具有搏动特点的偏头痛。钙是血管收缩的主要因素,钙经过通道进入平滑肌细胞时进行一系列化学反应而使平滑肌收缩。钙通道阻滞剂可抑制钙的内流,从而可抑制血管收缩,缓解或消除反应性的血管扩张。本文介绍钙通道阻滞剂治疗偏头痛的临床应用(附表)。
Mccarthy T et al. Drug Intell and Clin Pharm 1986; 20 (3): 199 The exact pathogenesis of migraine is unknown so far. Some people think that a substance has not been identified suddenly caused by a series of physiological phenomena, such as platelet aggregation, release of serotonin and thromboxane A 2, prostaglandin intensification, leading to local cerebral vasoconstriction and aseptic inflammation, followed by reaction Due to cerebral vasodilation, migraine with pulsatile characteristics can occur in pain-sensitive arterioles. Calcium is a major factor in vasoconstriction, and calcium enters the smooth muscle cells through the channel and undergoes a series of chemical reactions that cause the smooth muscle to contract. Calcium channel blockers can inhibit the influx of calcium, which can inhibit vasoconstriction, relieve or eliminate reactive vasodilation. This article describes the clinical application of calcium channel blockers for the treatment of migraine (Schedule).