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目的:探讨MR mDixon-Quant技术在精确测量2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量中的应用价值。方法:共纳入98例研究对象,其中糖尿病组(患有2型糖尿病)男33例,女16例,对照组(无2型糖尿病)男33例,女16例。所有研究对象均行肝脏3.0T MR mDixon-Quant检查,并测量肝脏脂肪含量(%)。以脂肪含量>5%作为脂肪肝的诊断标准。比较两组非酒精性脂肪肝检出率的差异。结果:糖尿病组肝脏脂肪含量中位数为5.5%(25分位值3.8%,75分位值11.0%),对照组肝脏脂肪含量中位数为3.7%(25分位值2.5%,75分位值5.7%)。糖尿病组脂肪肝总检出率为59.2%,对照组为28.6%。在男性研究对象中,糖尿病组脂肪肝检出率为63.6%(21/33),高于对照组(30.3%,10/33),差异有统计学意义(P<0.05);在女性研究对象中,糖尿病组脂肪肝检出率为50.0%(8/16),高于对照组(25.0%,4/16),但差异无统计学意义(P>0.05)。结论:采用MR mDixon-Quant技术可简便、精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量,可为疾病的筛查、诊断和治疗效果评估提供重要参考。
Objective: To investigate the value of MR mDixon-Quant in the measurement of liver fat content in type 2 diabetic patients with non-alcoholic fatty liver. Methods: A total of 98 study subjects were enrolled, including 33 males and 16 females with diabetes mellitus (type 2 diabetes mellitus), 33 males and 16 females in the control group (without type 2 diabetes mellitus). All subjects underwent liver 3.0T MR mDixon-Quant examination and liver fat content (%) was measured. Fat content of> 5% as a diagnostic criteria for fatty liver. Differences in the detection rates of non-alcoholic fatty liver between the two groups were compared. Results: The median liver fat content in diabetic patients was 5.5% (median 25 3.8% and negative 75% 11.3%), while the control group had a 3.7% median liver fat (2.5% at 25 and 75 points Bit value of 5.7%). The total detection rate of fatty liver in diabetic group was 59.2% and in control group 28.6%. Among the male subjects, the detection rate of fatty liver in diabetic group was 63.6% (21/33), which was higher than that in control group (30.3%, 10/33) (P <0.05) The detection rate of fatty liver in diabetic group was 50.0% (8/16), which was higher than that in control group (25.0%, 4/16), but the difference was not statistically significant (P> 0.05). Conclusion: MR mDixon-Quant technique can be used to measure the liver fat content of type 2 diabetes mellitus patients with non-alcoholic fatty liver easily and accurately. It can provide important reference for the screening, diagnosis and therapeutic evaluation of disease.