目的通过随机对照方法,观察马斯平在普胸外科围术期防治细菌性感染的有效性及安全性,并探讨其经济学效果。方法221例普胸外科手术患者,随机分为两组,围手术期分别给予马斯平和头孢他啶防治感染,观察各种感染情况,比较两组的临床效果并运用成本-效果分析法分析其经济学效果。结果实验组和对照组相比较,其防治术后感染的效果差别无显著性,而马斯平组成本-效果比低于头孢他啶组。结论普胸外科围术期应用马斯平防治细菌性感染是经济、安全和有效的。 Objective To observe the effectiveness and safety of maspin in the prevention and treatment of bacterial infections during perioperative thoracotomy by means of randomized controlled study and to explore its economic effects. Methods A total of 221 patients undergoing general thoracic surgery were divided into two groups at random. Mazapine and ceftazidime were given to prevent and treat infection respectively during the operation period. Various infections were observed. The clinical effects of the two groups were compared and the cost-effectiveness analysis was used to analyze their economics effect. Results The experimental group and control group compared the effect of prevention and treatment of postoperative infection was no significant difference, while the maspin group cost - effect ratio was lower than the ceftazidime group. Conclusion Perioperative perioperative application of maspin in the prevention and treatment of bacterial infections is economical, safe and effective.