《三仙丹》是中医外科临床常用的丹药之一。但是,关于《三仙丹》的作用机理和临床应用的论述,至今未见有专门的报道。我院自1970年5月以来,应用本院制剂室炼制的《三仙丹》治疗骨髓炎4000余例及其他疔毒、疮疡,痈疽等患者,均取得较为明显的疗效。现将个人临床应用《三仙丹》的粗浅体会,简述如下。《三仙丹》作用机理的初步探讨我院临床使用的《三仙丹》,系采用水银、火硝、枯矾三种矿物药作原料,经升丹方法炼制而成。方中火硝和枯矾均为氧化剂,可使水银变成汞的氧化物。我院炼制的《三仙丹》,将文献记载的《三仙丹》方中的白矾, “SanXiangDan” is one of the commonly used anti-inflammatory drugs in Chinese medicine surgery. However, no specific reports have been reported on the mechanism of action and clinical application of the “Sanxian Dan.” Since May 1970 in our hospital, the “Sanxian Dan” used in the hospital’s preparation room for the treatment of more than 4,000 cases of osteomyelitis and other patients with scrofula, sores, and phlegm has achieved significant results. Now we have a brief experience of personal clinical application of “Three Elixir”. Preliminary Study on the Mechanism of Action of the “Sanxian Dan” The “Sanxian Dan” clinically used in our hospital is made of three kinds of mineral medicines (mercury, nitrous oxide, and dry lanthanum) as raw materials and refined by Shengdan method. Both nitrite and dry ash are oxidizers, which can make mercury into the oxide of mercury. The “Three Elixirs” refined in our school records the whiteness of the “Sanxian Dan” written in the literature.