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目的观察10号染色体缺失且与张力蛋白同源的磷酸酯酶(PTEN)蛋白及血管内皮生长因子(VEGF)在肾癌组织中的表达及其临床病理意义。方法采用免疫组化法检测48例肾癌中PTEN及VEGF蛋白的表达。结果PTEN蛋白在癌旁组织及肾组织中的阳性率明显高于肾癌组织,而VEGF则相反。PTEN与VEGF蛋白表达呈负相关。结论PTEN蛋白表达降低与肾癌的临床分期,淋巴结转移密切相关,且与VEGF呈负相关。联合检测PTEN和VEGF有助于提高肾癌侵袭转移能力的评估,并可作为判定肾癌生物学行为的客观指标。
Objective To investigate the expression of PTEN protein and vascular endothelial growth factor (VEGF), a marker of absence of chromosome 10 and homology with tensinoprotein, in renal cell carcinoma and its clinicopathological significance. Methods Immunohistochemistry was used to detect the expression of PTEN and VEGF in 48 cases of renal cell carcinoma. Results The positive rate of PTEN protein in paracancer tissues and renal tissues was significantly higher than that in renal carcinoma tissues, while VEGF was the opposite. PTEN and VEGF protein expression was negatively correlated. Conclusions The decrease of PTEN protein expression is closely related to the clinical stage and lymph node metastasis of renal cell carcinoma, and it is negatively correlated with VEGF. Combined detection of PTEN and VEGF can improve the evaluation of invasion and metastasis of renal cell carcinoma, and can be used as an objective indicator to determine the biological behavior of renal cell carcinoma.