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目的探讨胃癌患者组织磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)的阳性表达与临床病理参数及预后的相关性。方法于2013年1月至12月对邯郸市中心医院收治的89例胃癌患者采用免疫组化法检测胃组织标本中p-mTOR的表达,分析其与淋巴结转移、浸润深度、组织分化程度和病理分期的相关性,并按p-mTOR的不同表达情况比较患者的预后。结果 p-mTOR阳性率为77.53%(69/89),其中有淋巴结转移的患者p-mTOR阳性率为90.20%,高于无淋巴结转移者的60.53%,差异有统计学意义(P<0.05);Spearman等级相关分析显示,p-mTOR的阳性表达与浸润深度、组织分化及肿瘤分期均呈正相关(P<0.01),相关系数分别为0.65、0.69和0.64。p-mTOR低表达组的疾病无进展中位生存期为23.5个月,显著长于高表达组的12.8个月,差异有显著统计学意义(P<0.01)。结论 p-mTOR在胃癌患者体内高表达,检测p-mTOR的表达有利于患者的预后评估。
Objective To investigate the relationship between the expression of p-mTOR and the clinicopathological parameters and prognosis of gastric cancer patients with phosphorylated mammalian target. Methods 89 gastric cancer patients admitted from Handan Central Hospital from January 2013 to December were enrolled in this study. The expression of p-mTOR in gastric tissues was detected by immunohistochemistry. The expression of p-mTOR was correlated with lymph node metastasis, depth of invasion, histological differentiation Staging of the correlation and p-mTOR according to the different expression of the prognosis of patients. Results The positive rate of p-mTOR was 77.53% (69/89). The positive rate of p-mTOR in patients with lymph node metastasis was 90.20%, which was higher than that in patients without lymph node metastasis (60.53%, P <0.05) ; Spearman rank correlation analysis showed that the positive expression of p-mTOR was positively correlated with the depth of invasion, tissue differentiation and tumor stage (P <0.01), the correlation coefficients were 0.65,0.69 and 0.64 respectively. The progression-free median survival of patients with low expression of p-mTOR was 23.5 months, significantly longer than that of the high-expression group (12.8 months), with significant difference (P <0.01). Conclusion p-mTOR is highly expressed in gastric cancer patients, and the detection of p-mTOR expression is helpful for the prognosis evaluation.