目的:分析研究生长抑素联合肠内、肠外营养支持治疗食管癌和贲门癌术后吻合口瘘的临床治疗效果。方法:给予收治的42例食管癌、贲门癌术后吻合口瘘患者,治疗方法不同划分为两组,甲组患者20例采用单纯全肠外营养支持治疗,乙组患者22例采用静脉生长抑素以及肠内、肠外营养支持治疗,对比分析病死率、瘘口愈合时间、胸腔闭式引流量以及胃肠减压量情况。结果:甲乙两组患者的病死率、瘘口愈合时间、胸腔闭式引流量以及胃肠减压量有显著性差异(P<0.05),有统计学意义。结论:持续静脉采用生长抑素联合肠内、肠外营养支持治疗食管癌和贲门癌术后吻合口瘘,疗效显著,有利于患者身体健康的早日恢复,安全高效。 Objective: To analyze the clinical effect of somatostatin combined with enteral and parenteral nutrition in the treatment of postoperative anastomotic leakage of esophageal and cardiac cancer. Methods: Forty-two patients with anastomotic fistula who underwent esophagectomy and cardia cancer after operation were divided into two groups according to different treatment methods. 20 cases of group A were treated with total parenteral nutrition alone, and 22 cases of group B were treated with intravenous And enteral parenteral nutrition support treatment, comparative analysis of mortality, fistula healing time, closed thoracic drainage volume and gastrointestinal decompression. Results: There was a significant difference between the two groups (P <0.05) in case fatality rate, fistula healing time, closed thoracic drainage volume and gastrointestinal decompression volume (P <0.05). CONCLUSION: Continuous intravenous administration of somatostatin combined with enteral and parenteral nutrition in the treatment of postoperative esophageal and cardiac cancer anastomotic fistulas has a significant curative effect, which is conducive to the early recovery of patients’ health and is safe and effective.