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目的探讨缺氧诱导因子1α(HIF-1α)在乳腺癌中的表达情况及对预后的影响。方法选取河南省肿瘤医院乳腺诊疗中心2006年7月至2007年3月手术切除的乳腺癌患者112例标本腊块,用免疫组织化学方法检测乳腺癌患者肿瘤组织中HIF-1α的表达情况,分析其与血管内皮生长因子(VEGF)及各项临床病理特征的关系和对预后的影响。结果乳腺癌患者肿瘤组织中HIF-1α阳性表达率为62.5%,HIF-1α阳性患者5年生存率为54.3%,显著低于HIF-1α阴性的乳腺癌患者(85.7%,P=0.001),HIF-1α与肿瘤的大小、TNM分期、组织分化程度和淋巴结有无转移相关,且与VEGF表达有相关性。结论 HIF-1α的表达促进VEGF表达,HIF-1α阳性患者有更差的预后及更短的生存时间,有可能成为乳腺癌预后预测的指标。
Objective To investigate the expression of hypoxia inducible factor 1α (HIF-1α) in breast cancer and its effect on prognosis. Methods Tissue samples from 112 patients with breast cancer resected from July 2006 to March 2007 in breast cancer center of Henan Cancer Hospital were collected for immunohistochemical detection of HIF-1α in breast cancer patients. Its relationship with vascular endothelial growth factor (VEGF) and its clinicopathological characteristics and prognosis. Results The positive rate of HIF-1α expression in breast cancer patients was 62.5%. The 5-year survival rate of HIF-1α-positive patients was 54.3%, significantly lower than that of HIF-1α-negative breast cancer patients (85.7%, P = 0.001) HIF-1α was correlated with tumor size, TNM stage, histological differentiation, lymph node metastasis, and VEGF expression. Conclusion The expression of HIF-1α promotes the expression of VEGF. HIF-1α-positive patients have worse prognosis and shorter survival time, which may be the prognostic indicator of breast cancer.