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博莱霉素所致肺急性(7d)与亚急性(21d)炎症时,肺内组织胺含量明显升高;而764-3则可使肺组织胺含量下降至接近正常。另外,组织胺对肺成纤维细胞具有时间及剂量依赖性促生长作用,764-3可抑制这一作用。提示组织胺在博莱霉素致肺纤维化中具有一定作用,764-3对这一过程有抑制作用。
Bleomycin-induced pulmonary acute (7d) and subacute (21d) inflammation, the lung tissue histamine significantly increased; and 764-3 lung tissue histamine levels can be reduced to near normal. In addition, histamine on lung fibroblasts with a time-and dose-dependent growth-promoting effect, 764-3 can inhibit this effect. Histamine suggests that bleomycin-induced pulmonary fibrosis has a role, 764-3 inhibition of this process.