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目的:探讨CAG方案治疗老年人急性髓系白血病(AML)疗效及不良反应。方法:共选择老年AML患者31例,治疗组19例应用CAG方案,对照组12例应用DA、HA或MA方案。结果:治疗组第一个疗程完全缓解(CR)率26.3%,有效率68.4%;第二疗程和第一疗程累计CR率为36.8%,有效率为89.4%。对照组第一疗程CR率为25.0%,有效率为66%。第二疗程和第一疗程累计CR率为33.3%,有效率为75.0%。两组比较第一疗程CR率、有效率差异均无统计学意义(P>0.05),第二疗程CR率差异无统计学意义(P>0.05),但有效率差异有统计学意义(P<0.05)。两组间骨髓恢复时间、所需浓缩红细胞及单采血小板数,差异有统计学意义(P<0.05)。结论:CAG方案治疗难治性老年人AML较其他普通化疗方案疗效肯定,同时较普通化疗方案骨髓抑制时间短,输血量减少。
Objective: To investigate the efficacy and adverse reactions of CAG regimen in the treatment of acute myeloid leukemia (AML) in the elderly. Methods: A total of 31 elderly patients with AML were selected. CAG was used in 19 patients in the treatment group and DA, HA or MA was used in 12 patients in the control group. Results: The complete remission (CR) rate was 26.3% and the effective rate was 68.4% in the first course of treatment. The cumulative CR rate of the second and first courses was 36.8% and 89.4% respectively. The control group, the first course of CR rate was 25.0%, the effective rate was 66%. The second course of treatment and the first course of the cumulative CR rate was 33.3%, the effective rate was 75.0%. There was no significant difference in CR rate and effective rate between the two groups (P> 0.05). There was no significant difference in CR rate of the second course of treatment between the two groups (P> 0.05), but the difference was significant (P < 0.05). The bone marrow recovery time, the concentration of required erythrocytes and apheresis platelets between the two groups were significantly different (P <0.05). Conclusion: The treatment of refractory AAG with CAG regimen is more effective than other chemotherapy regimens. In addition, the duration of myelosuppression and the volume of blood transfusion are lower than that of the conventional chemotherapy regimen.