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直立性蛋白尿一直被认为是一良性疾病,不会发展为慢性肾脏疾患。木文报告1例直立性蛋白尿发展为严重慢性肾小球疾病。患儿,男,15岁。尿常规检查发现蛋白++～++++,尿蛋白定量171mg/24h。连续3周测晨尿15次,11次蛋白(一),而直立性蛋白尿持续存在。无浮肿和全身性疾病的表现,血压60/100mmHg。多次检查无血尿、糖尿、脓尿和管型。血清肌酐0.7mg/dl、尿素氮12mg/dl、C_3、C_4、血沉、抗“O”、血清白蛋白、胆固醇均正常。诊为孤立的直立性蛋白尿。此后,近1年内,一般情况良好。约至1年后出现肾病综合症表现,浮肿、大量蛋白尿(8.1～14.79g/24h)低蛋白血症(1.8g/dl)和高胆固醇血症(611mg/dl),尿蛋白++++,镜下血尿,但无细胞管型。血清肌酐0.7mg
Erectile proteinuria has long been considered a benign disease, does not develop into chronic kidney disease. Wood reported 1 case of erect albuminuria developed severe chronic glomerular disease. Children, male, 15 years old. Urine routine examination found that protein ++ ~ ++++, urine protein quantitative 171mg / 24h. Cure for 15 consecutive weeks for 3 weeks, 11 proteins (a), while the persistence of orthostatic proteinuria. No edema and systemic manifestations, blood pressure 60 / 100mmHg. Multiple tests without hematuria, diabetes, pyuria and tube type. Serum creatinine 0.7mg / dl, urea nitrogen 12mg / dl, C_3, C_4, ESR, anti-O, serum albumin, cholesterol were normal. Diagnosis of isolated upright proteinuria. Since then, in the past year, the general situation is good. Nephrotic syndrome, edema, albuminuria (8.1-14.79 g / 24 h) hypoproteinemia (1.8 g / dl) and hypercholesterolemia (611 mg / dl) and urinary protein +++ +, Microscopic hematuria, but no cell tube. Serum creatinine 0.7mg