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目的探讨无创通气在治疗阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)合并高血压病中的作用,并通过随访了解无创通气在本类病例中对心脑血管疾病的预防作用。方法 92例患者均确诊为高血压病,同时行多导睡眠仪(PSG)监测均诊断为阻塞性睡眠呼吸暂停综合征(OSAS)。将92例患者随机分成A组(即无创通气治疗组,共48例)及B组(即非无创通气治疗组,共44例),两组患者均予以安慰剂治疗1个月,A组患者同时予以无创通气治疗,B组不予无创通气治疗;1个月后两组患者均根据血压情况继续调整降压药至达标,同时对两组患者进行5年随访,观察心脑血管事件的发生情况。结果 A组降压效果显著好于B组,B组心脑血管事件的发生率显著高于A组。结论对于阻塞性睡眠呼吸暂停综合征合并高血压病的患者通过无创通气的配合治疗,可以更好地控制血压,同时可减少心脑血管事件的发生。
Objective To explore the role of noninvasive ventilation in the treatment of hypertension complicated by obstructive sleep apnea syndrome (OSAS) and follow-up of non-invasive ventilation in the prevention of cardiovascular and cerebrovascular diseases. Methods Ninety-two patients were diagnosed as hypertension, meanwhile polysomnography (PSG) was used to diagnose obstructive sleep apnea syndrome (OSAS). Ninety-two patients were randomly divided into group A (n = 48) and group B (n = 44). Patients in both groups were treated with placebo for 1 month. Patients in group A At the same time non-invasive ventilation treatment, B group was not noninvasive ventilation; 1 month after the two groups were based on blood pressure continue to adjust antihypertensive drugs to reach the standard, while two groups of patients were followed up for 5 years to observe the occurrence of cardiovascular and cerebrovascular events Happening. Results The antihypertensive efficacy of group A was significantly better than that of group B, and the incidence of cardiovascular and cerebrovascular events in group B was significantly higher than that of group A. Conclusion In patients with obstructive sleep apnea syndrome complicated with hypertension, noninvasive ventilation can effectively control blood pressure and reduce cardiovascular and cerebrovascular events.