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目的 :增加替硝唑临床应用的剂型 ,满足妇科治疗滴虫性阴道炎和细菌性阴道炎的需要。方法 :采用半合成脂肪酸甘油酯为基质 ,以替硝唑和氧氟沙星为主药 ,按照制备栓剂的一般方法制备复方替硝唑栓。结果 :所得制剂疗效确切 ,无刺激性 ,且质量可控。结论 :复方替硝唑栓是值得临床推广的制剂。
Objective: To increase the dosage form of tinidazole clinical application to meet the needs of gynecological treatment of trichomonas vaginitis and bacterial vaginosis. Methods: The compound tinidazole suppository was prepared by the method of semi-synthetic fatty acid glycerides and tinidazole and ofloxacin as the main drugs. Results: The obtained preparation has definite effect, no irritation and quality control. Conclusion: The compound tinidazole suppository is worthy of clinical promotion.