论文部分内容阅读
目的研究炮制辅料羊脂油对淫羊藿炮制品提取物中主要活性成分宝藿苷I在大鼠体内药动学特征的影响。方法大鼠分别ig给予相同剂量(15 g/kg)的淫羊藿生品提取液、加热品提取液、羊脂油炙品提取液,HPLC-ESI-MS法测定大鼠宝藿苷I血药浓度,经DAS 2.0程序处理数据,比较宝藿苷I药动学参数。结果 3种淫羊藿炮制品提取物在血液中的达峰浓度(Cmax)、药时曲线下面积(AUC)等药动学参数大小为油炙品>加热品>生品,均具有统计学差异。结论羊脂油能促进淫羊藿提取物中宝藿苷I的口服吸收,提高其生物利用度。
Objective To study the effects of processing accessory material linoleic oil on the pharmacokinetics of the main active component treasure glycoside I in epimedium extract. Methods The rats were given the same dose (15 g / kg) of Epimedium Health Products extract, heating product extract, sunburn oil Sunburn extract, HPLC-ESI-MS method for the determination of rat icoside I blood Concentration, the data was processed by the DAS 2.0 program, comparing the pharmacokinetics parameters of rubroside I. Results The maximal blood concentration (Cmax), the area under the curve (AUC) and the pharmacokinetic parameters of the three kinds of Epimedium saponin extract in the blood ranged from: Sunburn products> heating products> raw products, difference. Conclusion The sheep tallow oil can promote oral absorption of icariin I in Epimedium extract and improve its bioavailability.