论文部分内容阅读
目的 观察福辛普利对充血性心力衰竭 (CHF)患者血浆内皮素 (ET)水平及心功能变化的影响 ,并探讨其相关机制。方法 86例CHF患者随机分为福辛普利组和常规治疗组 ,另有 38例健康受试者选为对照组 ,采用放射免疫法检测福辛普利组及常规治疗对照组患者治疗前和治疗 12周后ET水平 ,同时间点采用超声心动图检测左室射血分数 (LVEF)和二尖瓣血流最大流速E峰和A峰比值 (E/A)。结果 CHF患者ET水平显著高于对照组。福辛普利治疗 12周后 ,CHF患者的ET水平显著降低 ,LVEF、E/A值显著提高。结论 CHF患者ET水平增高可作为判断CHF病情的指标之一 ;福辛普利可降低CHF患者的ET水平 ,改善CHF患者的心脏功能。
Objective To observe the effect of fosinopril on plasma endothelin (ET) and cardiac function in patients with congestive heart failure (CHF) and to explore its related mechanism. Methods Totally 86 CHF patients were randomly divided into fosinopril group and conventional treatment group. Another 38 healthy subjects were selected as the control group. The patients in the fosinopril group and the routine treatment control group were detected by radioimmunoassay After 12 weeks of treatment, the level of ET was measured and the left ventricular ejection fraction (LVEF) and maximum velocity of mitral flow E peak and A peak ratio (E / A) were measured by echocardiography. Results The ET level in CHF patients was significantly higher than that in control group. Fosinopril 12 weeks after treatment, CHF patients with significantly decreased ET levels, LVEF, E / A value was significantly increased. Conclusion The increased ET level in CHF patients may be one of the indexes to judge the severity of CHF. Fosinopril may decrease the ET level in CHF patients and improve the cardiac function in CHF patients.