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目的:探讨联合测定血清孕酮及CA125在预测先兆流产预后的价值。方法:选择201例孕龄在5～12周的单胎孕妇,根据妊娠结局分为3组,正常妊娠组80例,先兆流产组68例,难免流产组53例,各组无年龄、孕产次及体重差异,测定血清孕酮及CA125水平。结果:安胎成功者孕酮水平高于流产组(P<0.05),CA125低于流产组(P<0.05)。以孕酮<16.3ng/ml为临界值,预测流产敏感性、特异性及准确性为86.2%、83.1%、85.2%,以CA125值>49.1U/ml为临界值,预测难免流产的敏感性、特异性及准确性分别为79.1%、81.2%、82.1%,如同时以孕酮<16.3ng/ml及CA125>49.1U/ml为临界值,预测难免流产的敏感性、特异性及准确性分别为78.3%、86.2%、90.1%。结论:在预测先兆流产预后的检测中,联合测定血清孕酮及CA125比单项测定指标的预测准确率明显提高。
Objective: To investigate the value of serum progesterone and CA125 in predicting the prognosis of threatened abortion. Methods: Totally 201 pregnant women with gestational age between 5 and 12 weeks were divided into 3 groups according to the pregnancy outcome, 80 normal pregnancy group, 68 threatened abortion group and 53 inevitable abortion group. There was no age, Times and weight differences were measured serum progesterone and CA125 levels. Results: The level of progesterone in successful tocolysis was higher than that in abortion group (P <0.05), and CA125 was lower than that in abortion group (P <0.05). With progesterone <16.3ng / ml as the critical value, the sensitivity, specificity and accuracy of abortion were predicted to be 86.2%, 83.1%, 85.2%, and the predictive value of the inevitable abortion was based on the cut-off value of CA125> 49.1U / ml , Specificity and accuracy were 79.1%, 81.2% and 82.1%, respectively. For example, the sensitivity, specificity and accuracy of prediction of unavoidable abortion were both cut off when the levels of <16.3ng / ml and CA125> 49.1U / ml Respectively 78.3%, 86.2% and 90.1%. Conclusion: In the prediction of the prognosis of threatened abortion, the combined detection of serum progesterone and CA125 significantly improves the prediction accuracy of the single measurement index.